BIRNA

Publications

Published research

Peer-reviewed research spanning intestinal barrier function, permeability, the microbiome and the microbiota–gut–brain axis.

  1. 2023

    Original Research · Transcriptomics

    Evaluating Prophylactic Effect of Bovine Colostrum on Intestinal Barrier Function in Zonulin Transgenic Mice: A Transcriptomic Study

    International Journal of Molecular Sciences · Vol. 24 · Issue 19 · Article 14730

    Birna Asbjornsdottir, Snaevar Sigurdsson, Alba Miranda-Ribera, Maria Fiorentino, Takumi Konno, Jinggang Lan, Larus S. Gudmundsson, Magnus Gottfredsson, Bertrand Lauth, Bryndis Eva Birgisdottir, Alessio Fasano

    A transcriptomic study investigating bovine colostrum intervention in zonulin transgenic mice, a model characterized by intestinal hyperpermeability and dysbiotic microbiota. RNA sequencing was used to explore molecular pathways and regulatory mechanisms associated with intestinal barrier function, immunity and inflammation.

    Evidence note: This is an animal-model study. Findings should not be presented as demonstrated clinical effects in humans.

    DOI: 10.3390/ijms241914730Original publicationPubMedPMC

  2. 2023

    Original Research · Microbiome & Behavior

    Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

    Biomedicines · Vol. 11 · Issue 1 · Article 91

    Birna Asbjornsdottir, Alba Miranda-Ribera, Maria Fiorentino, Takumi Konno, Murat Cetinbas, Jinggang Lan, Ruslan I. Sadreyev, Larus S. Gudmundsson, Magnus Gottfredsson, Bertrand Lauth, Bryndis Eva Birgisdottir, Alessio Fasano

    An experimental study examining whether bovine colostrum administration could modulate intestinal microbiota and behavior in wild-type and zonulin transgenic mice. The work connects microbial composition, intestinal barrier dysfunction and behavioral measures within the microbiota–gut–brain axis.

    Evidence note: This is an animal-model study. Results should not be generalized directly to human treatment or prevention.

    DOI: 10.3390/biomedicines11010091Original publicationPubMedPMC

  3. 2022

    Study Protocol

    Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study): A protocol for an observational longitudinal case-control study

    PLOS ONE · Vol. 17 · Issue 9 · Article e0273855

    Birna Asbjornsdottir, Bertrand Lauth, Alessio Fasano, Inga Thorsdottir, Ingibjorg Karlsdottir, Larus S. Gudmundsson, Magnus Gottfredsson, Orri Smarason, Sigurveig Sigurdardottir, Thorhallur I. Halldorsson, Viggo Thor Marteinsson, Valborg Gudmundsdottir, Bryndis Eva Birgisdottir

    A published protocol for a longitudinal case-control study designed to investigate relationships among diet, intestinal microbiota, intestinal permeability, metabolic factors and mental health in children and adolescents. The design integrates dietary data, validated mental-health measures and multiple biosamples in a multidimensional framework.

    Evidence note: This publication describes a study protocol and must not be represented as reporting completed study outcomes.

    DOI: 10.1371/journal.pone.0273855Original publicationPubMedPMC

  4. 2020

    Systematic Review & Meta-analysis

    Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis

    Nutrients · Vol. 12 · Issue 7 · Article 1982

    Birna Asbjornsdottir, Heiddis Snorradottir, Edda Andresdottir, Alessio Fasano, Bertrand Lauth, Larus S. Gudmundsson, Magnus Gottfredsson, Thorhallur Ingi Halldorsson, Bryndis Eva Birgisdottir

    A systematic review and meta-analysis examining evidence on intestinal permeability in children and adolescents diagnosed with mental disorders. Five observational studies involving ADHD, ASD and OCD were included, highlighting possible associations between intestinal barrier markers and neurodevelopmental disorders while also demonstrating substantial limitations and heterogeneity in the available evidence.

    Evidence note: Observational evidence can identify associations but does not establish causality.

    DOI: 10.3390/nu12071982Original publicationPubMedPMC